how can stochastics appoachs do?

[okanerkaymaz]

Dear Friends.
i have two Questions.


1- i wan to do with stochastic Na Channel my model but
i haven't this saubject
2- An other Question : i want to inject a Gauss noise in Soma in My Cell or together with IClamp

i will stochastic channel
for example white, rubenstein, fox lu
can i do a smilation with that Algorithms?

regards.

[ted]

1- i wan to do with stochastic Na Channel my model

The Channel Builder can be used for this. Channel gating must be specified as a kinetic
scheme (set of chemical reactions). I need to update the Channel Builder tutorial to show
how to do this.

2- An other Question : i want to inject a Gauss noise in Soma in My Cell or together with IClamp

Compute the noise current in advance and save it to a plain text file as (time, amplitude)
pairs (you can do this with your own hoc code in NEURON, or with Matlab, octave, C
etc.).
The read this file into a pair of Vectors and use the Vector class's play() method to
drive the current delivered by an IClamp. Go to the FAQ page
http://www.neuron.yale.edu/neuron/faq/general-questions
and read this item:
SEClamp and IClamp just deliver rectangular step waveforms. How can I make them produce an arbitrary waveform, e.g. something that I calculated or recorded from a real cell?
Also see the Programmer's Reference for information about Vector play()
http://www.neuron.yale.edu/neuron/stati ... .html#play

i will stochastic channel
for example white, rubenstein, fox lu
can i do a smilation with that Algorithms?

You will find a working example that qualitatively reproduces the findings of Chow &
White in ModelDB--
http://senselab.med.yale.edu/senselab/m ... odel=50391

A word about that particular paper: the unitary channel conductances assumed by
those authors were arbitrary. For the sake of illustration, the authors assumed a
particular number of channels, and divided the standard HH conductance densities
by those numbers to find the "unitary channel conductances."

[okanerkaymaz]

Dear Ted.
So much Tanks for Your help.
But i haven't very knowledge about Stochastics Algorithms and
can you send me more tutorials or journals web address about this objects ?