Search found 8 matches

by Quentin
Thu Mar 29, 2018 4:58 am
Forum: Other questions
Topic: spike propagation in a branched cell
Replies: 6
Views: 5441

Re: spike propagation in a branched cell

Thanks for your answer. I often see models in which a gigantic stimulus is used to elicit a spike--a stimulus large enough and long enough to contaminate the resulting action potential at the spike trigger zone. Is that what's happening with your model? I use different types of stimuli but the most ...
by Quentin
Wed Mar 28, 2018 6:49 am
Forum: Other questions
Topic: spike propagation in a branched cell
Replies: 6
Views: 5441

Re: spike propagation in a branched cell

Dear Ted, I apologize for the late answer. Thanks for your explanations on the HH mechanism. I ran hundreds of tests to make sure that each step was operated properly. And I also re-read Rattay et al 2001, Hear Res. I made sure the geometry and biophysics of my model was exactly as in their study an...
by Quentin
Thu Mar 15, 2018 9:40 am
Forum: Other questions
Topic: spike propagation in a branched cell
Replies: 6
Views: 5441

Re: spike propagation in a branched cell

Thanks for your answer. Here are details on the cell topology: [node-internode-...-node-Soma-node-internode...-node] soma: diam =30, L =20µm central axon : - diam = 2 µm - 11 nodes, L = 1.5 µm - 10 internodes, L = 100 µm peripheral axon : - diam = 1 µm - 6 nodes, L = 1.5 µm - 5 internodes, L = 100 µ...
by Quentin
Wed Mar 14, 2018 7:11 am
Forum: Other questions
Topic: spike propagation in a branched cell
Replies: 6
Views: 5441

spike propagation in a branched cell

Hi all, I am trying to simulate a linear fiber with a central axon, a soma and a peripheral axon. I used the dimensions given in Rattay et al, 2001, Hear Res.: central.diam=2 um, peripheral.diam=1um, soma.L =20 and soma.diam =30. However when using these parameters I am facing unexpected behaviors: ...
by Quentin
Tue Mar 06, 2018 3:39 am
Forum: Other questions
Topic: Extracellular stimulation of a model cell
Replies: 7
Views: 5198

Re: Extracellular stimulation of a model cell

Thanks, I'll have a close look at it.
Best,
Quentin
by Quentin
Mon Mar 05, 2018 4:56 am
Forum: Other questions
Topic: Extracellular stimulation of a model cell
Replies: 7
Views: 5198

Re: Extracellular stimulation of a model cell

Dear Ted, thanks for your help I checked the Model View and found nothing surprising. But I think I have identified several sources for my issues. 1/ I used values for gna_bar that were too low which I think are responsible for these periodic spikes. 2/ Once this problem solved I tried to implement ...
by Quentin
Fri Mar 02, 2018 5:14 am
Forum: Other questions
Topic: Extracellular stimulation of a model cell
Replies: 7
Views: 5198

Re: Extracellular stimulation of a model cell

Dear Ted, thank you so much for your reply. To make sure I did everything the right way I started all again from the very beginning as in the example you propose for beginners. I implemented a simple cell (one soma + one dendrite both with HH behaviors) and it seems to be a more general issue: When ...
by Quentin
Thu Mar 01, 2018 10:05 am
Forum: Other questions
Topic: Extracellular stimulation of a model cell
Replies: 7
Views: 5198

Extracellular stimulation of a model cell

Dear all, I am very new to Neuron and I also am facing troubles using extracellular stimulation. My goal is to evaluate the influence of various electrical stimuli (monophasic, biphasic, pseudo-monophasic... pulses) on a very simple model of an auditory nerve fiber. To do so I started studying the e...