Search found 4 matches

by aNNe
Wed May 22, 2019 8:41 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Stochastic gating as a function of external variable (light, membrane tension)
Replies: 3
Views: 803

Re: Stochastic gating as a function of external variable (light, membrane tension)

and have another mechanism that modifies the ligand concentration according to your desire function Oh, I never thought of that! Thanks for this idea! Also, could you please tell me on which basis, the KSChan method creates gating events. Is it also using the Gillespie algorithm, mapped onto discre...
by aNNe
Wed May 22, 2019 5:09 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Stochastic gating as a function of external variable (light, membrane tension)
Replies: 3
Views: 803

Re: Stochastic gating as a function of external variable (light, membrane tension)

Because the timing of individual openings and the validity for small copy numbers mattered in my application, I ended up implementing a Gillespie algorithm in a NMODL mechanism. It reproduces the kinetics of the mean field variant in the average of many reproductions and also for many channels. Surp...
by aNNe
Tue May 14, 2019 6:30 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Stochastic gating as a function of external variable (light, membrane tension)
Replies: 3
Views: 803

Stochastic gating as a function of external variable (light, membrane tension)

I would like to implement a mechanism that reflects ion channels gated by an external parameter, such as light intensity or membrane tension. The rate's dependency on the external parameter is not simply linear (quadratic, cubic), as in the case of gating triggered by binding one (two, three) ligand...
by aNNe
Thu Oct 23, 2014 5:46 pm
Forum: Other questions
Topic: na_ion mechanism not inserted in section axon
Replies: 15
Views: 8792

Re: na_ion mechanism not inserted in section axon

First let me thank you for fixing the bug in a blizz. Since we can change ena, the model performs exactly as we hoped. Going through the results, we realized, that two things are not completely clear to us. 1. the "location" at which the point process injects the current as you, Ted, pointed out ear...