www.neuron.yale.edu

Dear Ted, Thank you very much for the detailed answer. The rise time is 10-90, and the available data are both current clamp and voltage clamp of soma not far from the synapse. Does it make any sense to try to fit the given experimental IPSC amplitude (22 pA in my case), or it is hopeless due to flu...

Hi, How do you fit the experimental data on EPSP/IPSP kinetics? I have two time constants from experiment: "rise time" (3 ms) and "half-duration (width at half-amplitude)" (21 ms). I guess using Exp2Syn() mechanism should suffice? It also has two time constants tau1, tau2, but th...

Hi, Uri,
Thanks a lot for the PyNEURON. I just noticed on PyNEURON site that the link to installation instructions is broken due to a typo (https://bitbucket.org/uric/pyneuron/wiki/Instalation), double "l" in "Installation" is missing.

Ok, thanks!

Hi,
Would the standard d_lambda rule still applicable for a fast spiking axon, when interspike intervals are ~1.5-2 ms? The generic formula suggests is it still good for an axon which conducts trains of high-frequency spikes (>300 Hz)?
Thank you!

Your help is greatly appreciated!

Wow, Ted, many thanks for the code. It would take me days to figure out how to write this thing properly. In case any beginner needs complete code: after defining ns in Ted's code, just add objref nc axon nc = new NetCon(ns,ip) nc.threshold = 0 nc.weight = 1 nc.delay = 0 and enjoy the random spikes....

So, an external random number generator can stimulate axons via their NetStim's? I don't need to build in random numbers into NMODL file of the (synaptic) stimulation mechanism?

Hi, Ted, I am actually interested primarily in what happens in axons, with propagation failures and antidromic spikes. In principle, my model is all around axons, rather than soma and dendrites. Is there any way to implement the random drive to axons? I keep posting here because maybe our discussion...

These should be current pulses, delivered to distal axons and making them to spike 1 or more times, depending on pulse duration or amplitude. Waveform can be square, with parameters ton, amp as in generic Ipulse1 mechanism, and toff being a random exp. distributed variable. Any ideas to how implemen...

Hi, Ted,
I need some hundreds of pulses per network, pulses delivered to random cells at random times. Kind of Poisson noisy input for a network (100 cells or more, anatomically reconstructed).
Thanks,
Nik

I need a random time series of current pulses delivered to axon, with exponentially distributed times between successive pulses. How could I possibly do this?
Thank you!
Nik

Dear colleagues, Does anybody know a good manual for reconstruction of anatomically detailed models? I am new in the field, and there are some immediate questions to the topic: 1) After I open the swc file in import3D and save it as Neuron hoc file, is it good enough to populate with ion channels an...

This seems to be a common issue. I got same problem in swc file for cell http://neuromorpho.org/neuroMorpho/neuron_info.jsp?neuron_name=ca1a 1 1 2413. 1468. 1755. 5. -1 2 3 2412. 1468. 1755. 0.3 1 3 3 2411. 1469. 1755. 0.3 2 Maybe trivial, but worth mentioning: both diameter of soma apex and *its co...

Oh, that's what is symbolic constants. I always try to use this style, of course, and put all (most) controls at the top of code. I thought "symbolic constants" is something special :)
Thanks a lot, Ted!