The CellBuilder can be very helpful for specifying the spatial grid and biophysical properties of cell models that are based on detailed morphometric reconstructions. In this tutorial, we will construct a model cell that borrows the anatomy of the pyramidal neuron that is included with NEURON's demonstration program.
We'll use the CellBuilder to assign these biophysical properties to our model:
Throughout the cell cm = 1 uf/cm2, Ra = 160 ohm cm.
e_pas = -65 mV
g_pas = 3.333e-5 S / cm2 (Rm = 30,000 ohm cm2)
same as basliar dendrites
gnabar_hh and gkbar_hh reduced to 10%
gl_hh = 0 (already has g_pas)
We will follow this sequence of steps.
Step 1. Get the cell's anatomy into a CellBuilder
Step 2. Create subsets
Step 3. Specify the spatial grid
Step 4. Specify biophysics
Set up a strategy for specifying biophysics
Execute the strategy
Step 5. Use the model specification
Go back to the main page ("Using the Cell Builder") to work on a different tutorial.
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