Ineffective simulation with small duration current injection
Posted: Fri Aug 24, 2018 12:03 pm
hi everyone:
I'm a freshman in NEURON and recently encountered a problem.
When I was doing current injection(with h.IClamp method) into a 99-divided 20um diameter spherical soma inserted with 'pas' membrane mechanism, if duration is set to like 0.1ms and amplitude is 1nA, I got observable voltage response. But if the duration is 0.01ms and amplitude is 1000nA, no observbable response, the voltage does not change even 1 mV with time.
I would like to know whether this is limitation of time-step simulation, or some real biophysical phenomenon.
Thank you so much!
I'm a freshman in NEURON and recently encountered a problem.
When I was doing current injection(with h.IClamp method) into a 99-divided 20um diameter spherical soma inserted with 'pas' membrane mechanism, if duration is set to like 0.1ms and amplitude is 1nA, I got observable voltage response. But if the duration is 0.01ms and amplitude is 1000nA, no observbable response, the voltage does not change even 1 mV with time.
I would like to know whether this is limitation of time-step simulation, or some real biophysical phenomenon.
Thank you so much!