HH model and high temperature

[thats_karlo]

Hello every body.

First, " ted " .. i really appriciate for previuos answers that help me alot to undrestand Neuron. Thank's again!!!!!


Second, i rally confuse with HH model for the following simple case !!!(toturial--sthA.hoc)

creat soma
access soma
soma.nseg=1
soma.L=18.8
soma.diam=18.8
soma Ra=123.0
soma insert hh


with defualt value for temperature celsius=6.3 .

i run this program, i see sipke. (ok!)

but when i increse temerature celsius=32.3 i dont have spike. (ok??!)

so what should i do if i want to have spike in e.g. celsius=32 ?

should i write my HH mod file for Na and K? if yes, where can i find the rate constant for them in high temperature.

maybe you tell me that, the factor 3^(T-6.3)/10, is for temerature correction, but as i said , with HH defaul model in NEURON i don't have spike!


i await for your reply.

Thank you very much!

[ted]

Adjust stimulus intensity. Hint: stimulus duration should be short (0.1 ms or so).

A few facts about the Hodgkin-Huxley model:
1. It only spikes for stimuli that lie within a relatively narrow range of intensities.
2. As temperature increases, this range becomes even narrower, the spikes are
shorter in duration and lower in amplitude, and spike threshold increases.
3. It can still make a spike at 32 deg C, but not a very "healthy" one.

A comment about Ra and nseg: if nseg is 1, there is no longitudinal current spread,
so Ra will have no effect.