No capacitance in cortical cells from Bazhenov (2002)
Posted: Tue Sep 25, 2018 12:23 pm
I am interested in coding Bazhenov's sleep model ("Sleep-wake transitions in corticothalamic system," 2002) in NEURON. (ModelDB link: https://senselab.med.yale.edu/ModelDB/s ... 189#tabs-2)
In getting started, however, I immediately stumbled upon a curious feature of the model: the cortical pyramidal cell they use has two compartments (dendritic and somatic), and the somatic compartment has no capacitance! Here are their equations for the dendritic and somatic compartments (subscripts "D" and "S," respectively):
The authors of the 2002 paper state that the somatic compartment was characterized by such high conductance densities that including capacitance necessitated very small time steps for accurate integration. They therefore eliminated the capacitance in order to permit longer time steps.
My question is, can NEURON handle this? And if so, how? The Programmer's Reference says that capacitance is automatically inserted into every section, and I suspect that simply setting cm=0 will have dire consequences.
In getting started, however, I immediately stumbled upon a curious feature of the model: the cortical pyramidal cell they use has two compartments (dendritic and somatic), and the somatic compartment has no capacitance! Here are their equations for the dendritic and somatic compartments (subscripts "D" and "S," respectively):
The authors of the 2002 paper state that the somatic compartment was characterized by such high conductance densities that including capacitance necessitated very small time steps for accurate integration. They therefore eliminated the capacitance in order to permit longer time steps.
My question is, can NEURON handle this? And if so, how? The Programmer's Reference says that capacitance is automatically inserted into every section, and I suspect that simply setting cm=0 will have dire consequences.