Dominant Tau inTsodyks-Markram synapse model..?
Posted: Mon Sep 10, 2012 5:49 pm
Dear All,
One of the interesting points of Tsodyks-Markram model is the possibility to include facilitation,
This way three states are defined
x=> fraction of available synaptic resources but not active
y=> fraction or active synaptic resources
z=> fraction of inactive resources.
Such that
y converts to z with time constant t1, and z converts back to x with time constant trec
I want to study the non-facilitated problem and for that
I assume new y0 = y0 + x instead of new y0 = y0 + x · u with u the facilitation term. this because It results a very good and more realistic approach to study of the GABAA dynamics. than just one mono-exponential.
However, since this is a multi-state approach the total time of activation should be comparable with the tau in the mono-exponential case for the limit case, but I can not figure out how to set conditions for that limit case:
Should I assume that trec dominates the dynamics of the channel? or is it somehow a combination between t1 and trec?
Thanks a lot for any feedback!!
Best,
OJAG
One of the interesting points of Tsodyks-Markram model is the possibility to include facilitation,
This way three states are defined
x=> fraction of available synaptic resources but not active
y=> fraction or active synaptic resources
z=> fraction of inactive resources.
Such that
y converts to z with time constant t1, and z converts back to x with time constant trec
I want to study the non-facilitated problem and for that
I assume new y0 = y0 + x instead of new y0 = y0 + x · u with u the facilitation term. this because It results a very good and more realistic approach to study of the GABAA dynamics. than just one mono-exponential.
However, since this is a multi-state approach the total time of activation should be comparable with the tau in the mono-exponential case for the limit case, but I can not figure out how to set conditions for that limit case:
Should I assume that trec dominates the dynamics of the channel? or is it somehow a combination between t1 and trec?
Thanks a lot for any feedback!!
Best,
OJAG