Search found 7 matches

by xianghua
Fri Dec 20, 2013 6:27 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Re: Problems with adding paired pulse stimulations

I haven't figured out what the Graph[5] plots (image URL is insterted) https://drive.google.com/file/d/0B9ECtg ... sp=sharing
I just realised that this is another way of displaying ik, which overlayed ik from each of the repeated simulations. Cheers!
by xianghua
Thu Dec 19, 2013 1:03 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Re: Problems with adding paired pulse stimulations

Get this file http://www.neuron.yale.edu/ftp/ted/neuron/repsec.zip ... See what happens when you change del, num, invl, or any of the dur or amp parameters. Hi Ted, thank you so much. I managed to have RepSEC work, after attaching to my model which is modified from Traub hippocampal neuronal model....
by xianghua
Mon Dec 16, 2013 5:05 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Re: Problems with adding paired pulse stimulations

Hi Ted, thank you so much. I am working on the first method you mentioned ( "with an SEClamp and a state machine implemented entirely in hoc using an FInitializeHandler and cvode.event() ") to model the voltage clamp protocol. I am still struggling with NEURON. Would you please send me a w...
by xianghua
Fri Dec 13, 2013 6:30 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Re: Problems with adding paired pulse stimulations

But something is missing: what happens between trials. How long are the intertrial intervals--are they all of the same length? And what happens during each intertrial interval--is the model unclamped, or is it clamped to some holding potential? Finally, are you sure you're only going to want 5 tria...
by xianghua
Thu Dec 12, 2013 1:17 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Re: Problems with adding paired pulse stimulations

A sterotyped protocol sounds what I have been looking for. Specifically what? Basically everything, if possible, please. I don't have an idea where to start. I tried to examine how my slowly inactivating potassium channel responed to a 10ms 40mV depolarization by stimulating the cell with SEClamp a...
by xianghua
Thu Dec 12, 2013 12:12 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Re: Problems with adding paired pulse stimulations

Thank you, Ted. A sterotyped protocol sounds what I have been looking for. Looking forward to your further advice.
by xianghua
Thu Dec 12, 2013 9:35 am
Forum: Adding new mechanisms and functions to NEURON
Topic: Problems with adding paired pulse stimulations
Replies: 11
Views: 4729

Problems with adding paired pulse stimulations

Hi Ted, I am trying to examine the inactivation recovery rate of a slowly inactivating potassium chanel based on our wet-lab experiment result. The experiment is conducted using paired-pulse recovery protocol where we stimulates the cell with an depolarizing 20mV for 100ms after holding at -70mV. We...