Extracellular stimulation

[ssothro]

Hi all,
I am trying to apply the extracellular mechanism to a reconstructed pyramidal cell available in MODELDB. I want to simulate voltage-controlled extracellular stimulation, so I am giving to e_extracellular potentials values that correspond to field potentials I have calculated using a Finite Element model. Should I deal with every section of the cell or with every compartement of the cell, i.e. do I need to assign values to the center of each section (e_extracellular(0.5)) or should I assign e_extracellular values to the center of each compartment? To me the second approach makes more sense in terms of modeling, however the results I get when I use the first approach make more sense in terms of physiology. Could you please let me know which approach should I use in terms of e_extracellular, so that I know that at least that part of my code is OK?

Thank you in advance.

[ted]

This is the correct approach:

assign e_extracellular values to the center of each compartment?

Every segment's membrane should be exposed to its own local extracellular potential.