Connecting two sections, neither at the 0 or 1 ends

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Connecting two sections, neither at the 0 or 1 ends

Post by Robin-WR »

Although I know it is best to connect 0 and 1 ends of neuronal sections, I am currently working with a model that consists of spines, which connect along the length of a dendrite.

With my modelled spines consisting of cylinders each for the neck and head, I wondered how the flat, circular face of the neck's '0-end' connects to the long, curved face of the dendrite?

I may be moving on from modelling membrane voltage onto modelling calcium diffusion, and feel this may have a particularly large effect.

Thank you in advance.
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Re: Connecting two sections, neither at the 0 or 1 ends

Post by ted »

Very appropriate concerns.

Kristen Harris has done a lot of work on the morphology of spines and spiny dendrites at submicron resolution. Dig up her papers and check out Then start to wonder if such notions as "flat" and circular apply.

You're definitely going to be interested in reaction-diffusion modeling. Robert McDougal has been working on getting that going with NEURON; look up reports of his collaborations with Lytton and/or Hines, and also see Reaction-diffusion tutorials on the Documentation page of NEURON's web site Robert may also have some important tips to add to this thread, especially regarding how to translate submicron-resolution morphometric data from spines and dendrites into computational models.
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