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According to Wang et al in https://www.jneurosci.org/content/40/21/4103, (figure 2B) isoflurane inhibits presynaptic voltage-gated Ca2+ channels, the number of release sites (N), and the release probability (pr). Apologies for not mentioning this. I think it would be best to have a simulation with r...

C in the coh.mod is calcium.
From what I understand, I can use the rxd module for our anesthetic gas? Should I construct this in the GUI? If so, our gas is isoflurane. I think that this kind of reaction would follow hill kinetics. Also, what would I have to change in the coh.mod?

This equation defines the diffusion of a drug and the tissue response. We want to see how an anesthetic changes spike trains with different distance and concentration inputs. c is the concentration of anesthetic, x is the distance between a source and a neuron, Vmax is the tissue response due to the...

Hello, I am new to Neuron, coding in Nmodl, and am following the Neuron textbook. I am still having difficulty implementing my equation of interest and adding new variables to the GUI. The model that I would like to modify is https://senselab.med.yale.edu/modeldb/eavBinDowno=19747&a=23&mime=...