Search found 9 matches

by guanbc
Sat Jun 15, 2019 1:00 pm
Forum: Getting started
Topic: How to combine GUI with hoc programming
Replies: 3
Views: 1269

Re: How to combine GUI with hoc programming

Now that I have saved a workable ses. file for a simple GUI made model, and I want to change the ena from default by changing nao and nai. would you please give a concrete example; eg,I'd like nao and nai to be 44 mM and 50 mM respectively? the Neuron Book is still a bit too abstract. Should I write...
by guanbc
Sun Jun 09, 2019 12:24 pm
Forum: Getting started
Topic: How to combine GUI with hoc programming
Replies: 3
Views: 1269

How to combine GUI with hoc programming

A very basic question, which may sound silly. Now I can only do simple modeling using Neuron GUI and recreate the model by writing simple init.hoc that contains loading ses file information. I am wondering how to combine GUI with hoc programming to get more flexibility. After opening nrngui and recr...
by guanbc
Mon May 27, 2019 12:13 pm
Forum: Getting started
Topic: How to change the equilibrium potential of an ion species from the default to another value decided by its internal and
Replies: 1
Views: 941

How to change the equilibrium potential of an ion species from the default to another value decided by its internal and

We’d like to use a Na equilibrium potential different from the default value. Would you please give a concrete example of writing hoc commands to use the Na equilibrium potential produced by internal Na 50 mM and external Na 44 mM? I tried but always got error reminders.
by guanbc
Thu May 09, 2019 12:10 pm
Forum: Getting started
Topic: How to enter the parameters of a number of channels for a neuron?
Replies: 11
Views: 3872

Re: How to enter the parameters of a number of channels for a neuron?

1) Thanks a lot, Ted, for your great support! I tried as you said, it worked well. But, can we do it the other way round? That is, can I create the cell model first using Cell Builder and save it as ses. File, and then load it, and use it when I create channels using the Channel Builder? 2) If we ha...
by guanbc
Wed May 08, 2019 12:04 pm
Forum: Getting started
Topic: How to enter the parameters of a number of channels for a neuron?
Replies: 11
Views: 3872

Re: How to enter the parameters of a number of channels for a neuron?

Only using GUI, if I have created a cell using Cell Builder with hh Na and hh K channels. If I create another channel using Channel Builder, how can I insert this channel to that cell I have created? I mean, how can I insert the channel created by Channel Builder to the cell created by Cell Builder ...
by guanbc
Mon Mar 11, 2019 1:21 pm
Forum: Getting started
Topic: How to enter the parameters of a number of channels for a neuron?
Replies: 11
Views: 3872

Re: How to enter the parameters of a number of channels for a neuron?

Ted, Thank you very much for your detailed answers. They are very helpful to me. 1) By ‘capacitive transients’ I mean the electrode or membrane capacitance mediated charging/discharging currents while the clamping voltage changes in single electrode voltage clamp experiments. In real such experiment...
by guanbc
Thu Mar 07, 2019 4:25 am
Forum: Getting started
Topic: How to enter the parameters of a number of channels for a neuron?
Replies: 11
Views: 3872

Re: How to enter the parameters of a number of channels for a neuron?

After adjusting the initial potential, the result looked OK with flat baseline. Now several other questions: 1) How to removed the capacitive transients in SEClamp? 2) In the Channel Builder, is there a way to change the equilibrium potential value of HH sodium currents or HH potassium currents if w...
by guanbc
Sat Mar 02, 2019 10:18 pm
Forum: Getting started
Topic: How to enter the parameters of a number of channels for a neuron?
Replies: 11
Views: 3872

Re: How to enter the parameters of a number of channels for a neuron?

I tried a simple SEClamp "experiment"after entering a HH Na Channel and a HH K channel in the Cell builder(instead of in the Channnel Builder).Basically, it seemed OK and the i-t curve looked like what I expected. There are two problems: 1) I used a three-epoch voltage stimulation, the first and the...
by guanbc
Sat Feb 23, 2019 12:15 am
Forum: Getting started
Topic: How to enter the parameters of a number of channels for a neuron?
Replies: 11
Views: 3872

How to enter the parameters of a number of channels for a neuron?

I am a beginner to studying NEURON, and have just read some relevant materials online. Now my colleague has given me the list of channels existing in a species of neuron she is studying, including 9 channels (eg.A channel, Kdr channel, HCN channel, Nav, CaHVA...) with their maximal conductances, rev...