Search found 49 matches
- Fri Jun 22, 2018 6:18 pm
- Forum: Other questions
- Topic: Sodium and Potassium current
- Replies: 6
- Views: 4507
Sodium and Potassium current
I am working on model of soam using three different voltage gated channels Na,K and Ca, three different leak channels and three different channels of pump for the same ion. I am trying to use theses channels to get a resting value of concentrations after injecting it with certain current u=in the mi...
- Thu Jun 21, 2018 1:38 pm
- Forum: Parallel NEURON
- Topic: Stabilization Mechanism
- Replies: 9
- Views: 16611
Re: Stabilization Mechanism
After adding this condition to the na/K pump BREAKPOINT { inapump = ipumpmax*(1/(1 + pow(km/nai,n))) if(nai <= 10 ){ inapump = 0 }else{ inapump = ipumpmax*(1/(1 + pow(km/nai,n))) } ina = 3.0*inapump if(ki >= 140 ){ inapump = 0 }else{ inapump = ipumpmax*(1/(1 + pow(km/nai,n))) } ik = -2.0*inapump } T...
- Thu Jun 21, 2018 12:49 pm
- Forum: Parallel NEURON
- Topic: Stabilization Mechanism
- Replies: 9
- Views: 16611
Re: Stabilization Mechanism
Thanks for those information. I used that Nadifl.mod in my file.hoc. regarding to the Nadifl.mod, does that file included calculate diffusion and migration terms, that is , {diffusion constant *delta(concentration)/dlta(x)}+{mobility * concentration* delta(poteial )/delta (x)} or just {diffusion con...
- Tue Jun 19, 2018 5:27 pm
- Forum: Parallel NEURON
- Topic: Stabilization Mechanism
- Replies: 9
- Views: 16611
Re: Stabilization Mechanism
Once again thank you. The concentrations has been calculated at nadifl, kdifl and cadifl .mod , so do I have to add the concentrations calculation in the same pump file or I can do it separately like what I did. Secondly, after doing your correction to the code I still have problem with potassium co...
- Tue Jun 19, 2018 2:20 pm
- Forum: Parallel NEURON
- Topic: Stabilization Mechanism
- Replies: 9
- Views: 16611
Re: Stabilization Mechanism
Thank you for replay, the flowing are the file.hoc nad pump.mod Which I used in my code. [create soma soma { nseg = 101 L = 100// [µm] length diam = 0.1 // [µm] diameter insert hh gnabar_hh = 0.120 // [S/cm^2] gkbar_hh = 0.036 // [S/cm^2] glbar_hh = 0.0000 // [S/cm^2] //gcabar_hh = 0.12 // [S/cm^2] ...
- Mon Jun 18, 2018 1:43 pm
- Forum: Parallel NEURON
- Topic: Stabilization Mechanism
- Replies: 9
- Views: 16611
Stabilization Mechanism
I am trying to simulate soma with sealed ends. I have used three ions Na, K and Ca, and injected current was 50 pA for 0.2 ms duration the length of this soma 100 micro-meter and diam=0.1 micrometer. I used three voltage gated channels for Na,K and Ca and Na/K pump. I am trying to find the concentra...
- Wed Jun 13, 2018 3:20 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
[Second step: Use your browser to search the hits for the exact string
WRITE nai
or
WRITE ki
Case is important! Avoid any hits that
WRITE Nai
or
WRITE Ki]
can you tell me how ?
WRITE nai
or
WRITE ki
Case is important! Avoid any hits that
WRITE Nai
or
WRITE Ki]
can you tell me how ?
- Wed Jun 13, 2018 12:02 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
I would like to use activation mechanism of calcium is similar to that of sodium current channel, so is there a simple way to do that by using the standard HH for sodium to my max. calcium conductance?
- Tue Jun 12, 2018 4:43 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
Does the low threshed calcium current model different from squid to the others.
- Mon Jun 11, 2018 1:39 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
Thank you.The last comment was important.
- Mon Jun 11, 2018 1:08 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
So in this case I have to create file.mod to calculate calcium current . Is there example I can use it for this purpose ?
- Mon Jun 11, 2018 12:25 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
Thank you Ted. I am trying to add calcium to my code but when drew the calcium concentration with time there is no curve show up in the graph. insert hh gnabar_hh = 0.120 // [S/cm^2] gkbar_hh = 0.036 // [S/cm^2] glbar_hh = 0.0003 // [S/cm^2] gcabar_hh = 0.32 // [S/cm^2] cm=1 // [uF/cm2] Ra=89.9 //oh...
- Sun Jun 10, 2018 1:45 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
Anyone can help me to do Na/K restoration process, which pushes the concentrations back to equilibrium, because right now the sodium and potassium go up at a certain time and stay constant. is there mechanism to push them back to the resting value.
- Fri Jun 08, 2018 5:01 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
thanks for explanation. that means the basic equation is Fick's second law,because I am looking for the differential equation that has been used to find the concentration in nadifl. You can find it here:
https://en.wikipedia.org/wiki/Fick%27s_ ... _diffusion
https://en.wikipedia.org/wiki/Fick%27s_ ... _diffusion
- Fri Jun 08, 2018 2:55 pm
- Forum: NEURON + Python
- Topic: Neuron code
- Replies: 20
- Views: 15746
Re: Neuron code
Did you mean that LONGITUDINAL_DIFFUSION
del C/del t=del2 C/del2 x
so it is just Fick's second law.
del C/del t=del2 C/del2 x
so it is just Fick's second law.