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channel density gradient in dendrites?

Posted: Tue Oct 31, 2006 9:12 am
by jamie
I would like have the density of a certain channel on a gradient from the soma to the tip of the dendritic tree. Is there any good .hoc way to set this up?

- with perhaps the ability to give the value at the soma and then some gradient value to dictate how much we taper away from this in the dendrites - to give the slope of the gradient perhaps? Or perhaps to give the density value at the soma and the density value at the tip - and then the coding assorts the densities in between accordingly.

Once again, thanks so, so much.

Posted: Tue Oct 31, 2006 10:55 am
by ted
Do it with the CellBuilder--see http://www.neuron.yale.edu/neuron/stati ... /main.html
If you are dealing with an existing model specified in hoc, and don't want to replicate it with
the CellBuilder, then
1. make a toy model with the CellBuilder and specify the desired spatial variation of parameter(s)
2. export from that CellBuilder to a hoc file
3. examine that hoc file to find the stuff that sets up the spaitally inhomogeneous parameter(s)
4. adapt that code to your own needs