Switching L2/3 morphology in model but preserving intrinsic and synaptic properties.

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alexandrapierri
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Switching L2/3 morphology in model but preserving intrinsic and synaptic properties.

Post by alexandrapierri »

Hello

I am using the following model by Aberra 2018 (https://senselab.med.yale.edu/modeldb/S ... del=241165). I would like to replace the L23 morphology file with my own morphology file but preserve the synaptic distribution and intrinsic properties of the cell. If I simply replace the file obviously a lot of synaptic inputs will appear to be out of range as the dendritic distribution between the two morphologies is not exactly the same. Is there an automatic way I can scale the synaptic inputs and intrinsic property distributions to the new morphology without having to manually recreate those inputs and ion channel properties?

thank you,
Alexandra
ted
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Re: Switching L2/3 morphology in model but preserving intrinsic and synaptic properties.

Post by ted »

Is there an automatic way I can scale the synaptic inputs and intrinsic property distributions to the new morphology
Nothing is automatic. You have to understand the procedures/functions that the original authors used to govern distribution of channels, synapses, etc., and decide what changes are needed to accomplish what you want to do with your cell's morphology.
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