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Receptor Mechanisms at the Same Location on a Cell

Posted: Thu Feb 26, 2015 11:20 pm
by dabliss
I have a point-process NMDA receptor mechanism (NMDASyn) that I'd like to place at the center of my single-compartment neuron. However, rather than have just one instance of NMDASyn, I'd like a new one for every connection my cell makes. Is it OK to have all these instances of NMDASyn placed at the same location in my cell? How should I expect their effects on V_m to be summed?

Thanks,
Dan

Re: Receptor Mechanisms at the Same Location on a Cell

Posted: Fri Feb 27, 2015 12:39 am
by ted
dabliss wrote:Is it OK to have all these instances of NMDASyn placed at the same location in my cell?
Yes.
How should I expect their effects on V_m to be summed?
Each one will generate its own current. NEURON knows how to deal with charge balance.