www.neuron.yale.edu

Hi,
How are you?

I was playing with the sodium balance in a simple soma model. I saw Dr. Canavier's model
http://senselab.med.yale.edu/modeldb/sh ... model=6763
I could not find the sodium balance equation (8) from her paper in her NEURON model file. Can you help me?
Thank you!

Regards,

Xianghong

Sodium accumulation is managed by the mechanism that WRITEs a sodium concentration.
In this model, that mechanism is nadifl.mod. The USEION na READ ina WRITE nai statement
in the NEURON block ensures that this mechanism collects the sodium currents that are
generated by mechanisms that WRITE ina. The sum of those currents becomes the value
of the ina that is declared in the ASSIGNED block. The effect of this net ina on sodium
concentration is specified by the statement
~ nai << (-ina/(FARADAY)*PI*diam*(1e4))
in the KINETIC conc block, which asserts that a segment's net transmembrane current ina is
a flux of sodium into that segment. The LONGITUDINAL_DIFFUSION D (nai) statement
specifies that there is exchange of sodium between adjacent segments. From these
statements, nrnivmodl (mknrndll) sets up the matrix elements that take transmembrane
sodium flux and longitudinal diffusion of sodium into account.

thanks, Ted:
That is helpful!

Xianghong