I' working with the cell builder on an anatomically detailed model. At the moment I'm trying to find a parameter set, where the model exhibits a 3-Spike-Burst.
Therefore I changed the conductances on the biophysics page in the cell builder. Finally I found a a set of parameters showing the desired behaviour. I saved the session and closed NEURON. Afterwards I started NEURON again and loaded the saved session. Surprisingly the model exhibited only a 2-Spike-Burst. Checking every parameter three or four times I'm sure that the parameter sets are identical. Then I changed one of the conductances in the cell builder, but reversed it immediately. I ran the simulation again and the model showed the desired 3-Spike-Burst.
So in a nutshell I did:
- found parameter set, which produces a 3-Spike-Burst
- saved session
- closed NEURON
- started NEURON, loaded session
- ran simulation -> 2 Spike Burst
- changed arbitrarily one conductance and reversed the change immediately in the cell builder ***
- ran simulation -> 3 Spike Burst
*** Maybe it is useful to mention that changing the parameter in hoc (with a script) does not lead to a 3-Spike-Burst, but to a 2-Spike-Burst
I use Ubuntu and NEURON 5.9, but I tried it also with NEURON 6.0 on a windows XP-machine.
Does anyone have an idea what the cell builder does, when a parameter is changed? "Continous Create" is on.
By the way I exported the cell to hoc and tried to reload it, but it produces an error
. The model is pretty large (256 sections with different parameters). Can this be connected to my problem ???procedure too big