### Dominant Tau inTsodyks-Markram synapse model..?

Posted:

**Mon Sep 10, 2012 5:49 pm**Dear All,

One of the interesting points of Tsodyks-Markram model is the possibility to include facilitation,

This way three states are defined

x=> fraction of available synaptic resources but not active

y=> fraction or active synaptic resources

z=> fraction of inactive resources.

Such that

y converts to z with time constant t1, and z converts back to x with time constant trec

I want to study the non-facilitated problem and for that

I assume new y0 = y0 + x instead of new y0 = y0 + x · u with u the facilitation term. this because It results a very good and more realistic approach to study of the GABAA dynamics. than just one mono-exponential.

However, since this is a multi-state approach the total time of activation should be comparable with the tau in the mono-exponential case for the limit case, but I can not figure out how to set conditions for that limit case:

Should I assume that trec dominates the dynamics of the channel? or is it somehow a combination between t1 and trec?

Thanks a lot for any feedback!!

Best,

OJAG

One of the interesting points of Tsodyks-Markram model is the possibility to include facilitation,

This way three states are defined

x=> fraction of available synaptic resources but not active

y=> fraction or active synaptic resources

z=> fraction of inactive resources.

Such that

y converts to z with time constant t1, and z converts back to x with time constant trec

I want to study the non-facilitated problem and for that

I assume new y0 = y0 + x instead of new y0 = y0 + x · u with u the facilitation term. this because It results a very good and more realistic approach to study of the GABAA dynamics. than just one mono-exponential.

However, since this is a multi-state approach the total time of activation should be comparable with the tau in the mono-exponential case for the limit case, but I can not figure out how to set conditions for that limit case:

Should I assume that trec dominates the dynamics of the channel? or is it somehow a combination between t1 and trec?

Thanks a lot for any feedback!!

Best,

OJAG