### Understanding Frankenhaeuser Huxley (FH)

Posted:

**Fri Oct 14, 2011 2:28 am**Hello!

I am new to the neuron simulation environment

I am currently having difficulty understanding the FH program on modelDB.

There seems to be some discrepancies between the leakage reversal potential in the actual paper and the program in modelDB.

The discrepancy seems to be quite large with the paper indicating that the reversal potential should be 0.026mV and the modelDB program using the value -69.74mV.

What’s interesting is that even with such a discrepancy the modelDB program outputs the same graphs as those in the paper.

I have also tried simulating the equations in matlab but to no avail as I'm getting stability issues even with robust algorithms such as ODE15s. The gating variables don’t seem to want to turn to the correct directions.

Any help would be greatly appreciated.

Matlab Simulation Graph:

FH ModelDB:

http://senselab.med.yale.edu/modeldb/Sh ... model=3507

FH Original Paper:

http://jp.physoc.org/content/171/2/302.full.pdf

I am new to the neuron simulation environment

I am currently having difficulty understanding the FH program on modelDB.

There seems to be some discrepancies between the leakage reversal potential in the actual paper and the program in modelDB.

The discrepancy seems to be quite large with the paper indicating that the reversal potential should be 0.026mV and the modelDB program using the value -69.74mV.

What’s interesting is that even with such a discrepancy the modelDB program outputs the same graphs as those in the paper.

I have also tried simulating the equations in matlab but to no avail as I'm getting stability issues even with robust algorithms such as ODE15s. The gating variables don’t seem to want to turn to the correct directions.

Any help would be greatly appreciated.

Matlab Simulation Graph:

FH ModelDB:

http://senselab.med.yale.edu/modeldb/Sh ... model=3507

FH Original Paper:

http://jp.physoc.org/content/171/2/302.full.pdf