SarahJansky wrote:I can add Iclamp but couldnt define the suprathreshold level of the model.
I mean : when we get the "membrane area" 1000 um2 (approx. deterministic) neuron fires for a value in Iclamp, but if we increase the area (nearest to deterministic model) it fires with another value of Iclamp. in real these values must be the same.
Voltage-dependent channels are gated by changes of membrane potential. Bigger area
means more membrane capacitance. More membrane capacitance means more charge must
accumulate in order to produce a given change of membrane potential. If IClamp current
duration remains constant, the only way to deliver more charge is to increase the current
Also in program demo: Ik, INa are determined as (ms/cm2), but we use in Iclamp (nA), I think there is a units problem
"program demo" means what?
http://senselab.med.yale.edu/modeldb/sh ... odel=50391
i.e. the program in ModelDB that qualitatively replicates the findings published in Chow &
White (1996)? or do you refer to the "NEURON demo" program?
(ms/cm2) is milliseconds per square centimeter, which would be very strange units for
Perhaps you are confused about the difference between a "density mechanism" (also
called a "distributed mechanism") and what is called a "point process" in NEURON.
This is discussed in 5.6 How to specify biophysical properties
in The NEURON Book;
if you don't have that, see 4.6 Density mechanisms and point processes
in our paper
Hines, M.L. and Carnevale, N.T. The NEURON simulation environment.
Neural Computation 9:1179-1209, 1997.
which is available online in an enhanced version