intracellular sodium ion accumulation

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Sun Xiaoqing
Posts: 32
Joined: Wed Aug 28, 2019 1:18 am

intracellular sodium ion accumulation

Post by Sun Xiaoqing » Sat Sep 21, 2019 12:44 am

Hi,

I'm trying to simulate the intracellular electric field gerneated by the action potential propagating along the myelinated axon with the influence of sodium ion accumulation at the Node of Ranvier.

For the uniform myelinated axon and its initialization, I used the cable.hoc and init.hoc from:
https://senselab.med.yale.edu/modeldb/S ... model=9851

Then I tried to use the nacum.mod file from:
https://senselab.med.yale.edu/modeldb/S ... 800#tabs-1
I put cable.hoc, init.hoc and nacum.mod file into another new created file called ''new model'', and use mknrndll to compile ''new model''.
  • After compiling the file, it showed that nrnmech.dll was built successfully. Did that mean that the intracellular sodium ion accumulation mechanism was successfully inserted to my model?

    I want to insert the sodium ion accumulation mechanism into the Node of Ranvier, what modification that I have to apply to my model?

    I also wonder how to record the intracellular voltage along the axon and save it to another file which I want to use later in Matlab to plot the electric field.
Please excuse me for my relatively simple questions, I've been browsing the forum and I still got these confusion. i'm willing to take any suggesstion from you. Thanks in advance.

Kind regard,
SUN XIAOQING

Sun Xiaoqing
Posts: 32
Joined: Wed Aug 28, 2019 1:18 am

Re: intracellular sodium ion accumulation

Post by Sun Xiaoqing » Sun Sep 22, 2019 2:04 am

When browsing the forum, I noticed that combining different parts from other models to create a new model wasn't easy, so if I could modify the original code from Extracellular Action Potential Simulation:https://senselab.med.yale.edu/ModelDB/S ... 589#tabs-1
the attempt to create my own model is not that necessary and I'll focus on making the original model work. Please see my other posts about 'reuse Extracellular Action Potential Simulation model'', if you have any idea how should I modify the code according to the error messages, Thank you.

I'm so sorry for my indecisiveness thanks for all your patient replies.

ted
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Re: intracellular sodium ion accumulation

Post by ted » Thu Sep 26, 2019 2:00 pm

Since you're working with hoc, you should read this ASAP:
Hines, M.L. and Carnevale, N.T. The NEURON Simulation Environment Neural Computation 9:1179-1209, 1997.
https://neuron.yale.edu/neuron/static/p ... /nctoc.htm
You might want to download the preprint, which is available from a link on that page.

Every time you run into a keyword that is new to you, read about it in the hoc version of the Programmer's Reference
https://www.neuron.yale.edu/neuron/stat ... index.html

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