Hi everybody!
i'm new student in neuroscince. and i want to know how this software is working,
i read "toturial A" .and i have some questions, could you please explaine me some things;
1- which parameter define membranr resistance Ra?
in toturial A , Ra is defined as axial resistancs and in FAQ (What units does Neuron...)
Ra is cytoplasmic resistance!!
2- How i can change temperatute in HH model?
3- How i can change concentration of ions?
4- How can i change membrane time constant?
5- I know that , HH model inculde Na and K , these ions are resposible for generation one action potential. Could you tell me, How can i test this hypothesis;
incrasing the external calcium concentration will block occurance of the action potential
i will be thankfull if somebodu answer me soon!!!
Regards, KARLO
Hodgkin-Huxley parameters
Hodgkin-Huxley parameters
Last edited by thats_karlo on Thu Sep 08, 2005 8:35 pm, edited 2 times in total.
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OK, short answers.
Ra isn't membrane resistance, it's cytoplasmic resistivity.
Read the documentation. Start with the papers listed on the Documentation page
at NEURON's web site.
Read about it in the Programmer's Reference.
http://www.neuron.yale.edu/neuron/stati ... c.html#ion
and "Expanding NEURON's Repertoire of Mechanisms with NMODL"
Get that from the Documentation page on the web site.
properties.
Implement this model in NEURON, and use it in simulations in which you change [Ca]
and observe what happens to excitability.
There is no membrane resistance parameter in NEURON.1- which parameter define membranr resistance Ra?
Ra isn't membrane resistance, it's cytoplasmic resistivity.
Read the documentation. Start with the papers listed on the Documentation page
at NEURON's web site.
So? You just called it membrane resistance. Who do you think is right?in toturial A , Ra is defined as axial resistancs and in FAQ (What units does Neuron...)
Ra is cytoplasmic resistance!!
celsius2- How i can change temperatute in HH model?
Read about it in the Programmer's Reference.
Read this3- How i can change concentration of ions?
http://www.neuron.yale.edu/neuron/stati ... c.html#ion
and "Expanding NEURON's Repertoire of Mechanisms with NMODL"
Get that from the Documentation page on the web site.
Change cm and/or ionic conductances.4- How can i change membrane time constant?
Create a conceptual model that clearly states how you think calcium affects membraneHow can i test this hypothesis;
incrasing the external calcium concentration will block occurance of the action potential
properties.
Implement this model in NEURON, and use it in simulations in which you change [Ca]
and observe what happens to excitability.