Search found 71 matches

by menica
Mon Oct 10, 2016 1:03 pm
Forum: Getting started
Topic: synapse eith single source , multiple targets
Replies: 5
Views: 6544

Re: synapse eith single source , multiple targets

Dear Ted,
I don't have any error message.
The problem is that with my code I am able to insert 3 synapses at the same dend[2], but I would like insert in each of the dend[0], dend[1], dend[2] one synapse.

I cannot find the way

best
Menica
by menica
Mon Oct 03, 2016 7:02 am
Forum: Getting started
Topic: synapse eith single source , multiple targets
Replies: 5
Views: 6544

Re: synapse eith single source , multiple targets

Dear Ted,
sorry my mistake in reporting the code.
It is:

Code: Select all

L5PC.dend[k] synE[i] = new Exp2Syn(0.5)
by menica
Fri Sep 30, 2016 11:45 am
Forum: Getting started
Topic: synapse eith single source , multiple targets
Replies: 5
Views: 6544

synapse eith single source , multiple targets

Dear all, I would like to insert a synapse in each of the 3 dendrites in my post-neuron The source would be the same for all (the V of the pre-neuron (soma) ) I attempted this code nmaxsynE=3 ndend=3 objref ncl, ntc, synE[nmaxE] ncl=new List() for k=0,ndend{ for i=0, nmaxE { L5PC.apic[0] synE[i] = n...
by menica
Tue Sep 06, 2016 9:13 am
Forum: Other questions
Topic: Segmentation violation in Hay. et. al model
Replies: 1
Views: 4333

Segmentation violation in Hay. et. al model

Hi, I tried to run the following commands: load_file("nrngui.hoc") load_file("import3d.hoc") objref L5PC strdef morphology_file morphology_file = "../morphologies/cell1.asc" load_file("../models/L5PCbiophys3.hoc") load_file("../models/L5PCtemplate.hoc") L5PC = new L5PCtemplate(morphology_file) using...
by menica
Tue Jul 26, 2016 8:39 am
Forum: Other questions
Topic: wrong initialization or wrong mechanisms?
Replies: 9
Views: 5940

Re: wrong initialization or wrong mechanisms?

Hi, this is just a remind for my previous post :)
by menica
Fri Jul 08, 2016 9:33 am
Forum: Other questions
Topic: wrong initialization or wrong mechanisms?
Replies: 9
Views: 5940

Re: wrong initialization or wrong mechanisms?

Dear Ted, thanks for the answer. You're trying to use an electrogenic pump mechanism that has a 3:2 stoichiometry in a model cell that lacks all of the stuff found in real cells that allows such a pump to work without disrupting ionic equilibrium potentials and resting potential.....do you stick wit...
by menica
Wed Jul 06, 2016 8:18 am
Forum: Other questions
Topic: wrong initialization or wrong mechanisms?
Replies: 9
Views: 5940

Re: wrong initialization or wrong mechanisms?

Dear Ted, to adjust the active transport mechanism's parameters so that the Na and K fluxes it generates exactly cancel out the membrane currents generated by whatever Na and K ion channels are present when the cell is initialized it means that the initialization procedure I wrote is not correct? I ...
by menica
Tue Jul 05, 2016 4:27 am
Forum: Other questions
Topic: wrong initialization or wrong mechanisms?
Replies: 9
Views: 5940

wrong initialization or wrong mechanisms?

dear Ted, I am working with 2 cell connected by an Expsyn. The first cell is 1 comp. (soma), the second cell is 2 comp (soma+dend). I am using the na and k channels mechanisms by Migliore https://senselab.med.yale.edu/ModelDB/ShowModel.cshtml?model=149415&file=/MiglioreMcTavish2013/kdrmt.mod#tabs-2 ...
by menica
Tue May 24, 2016 10:37 am
Forum: Optimization
Topic: Exploring parameter space
Replies: 5
Views: 7527

Re: Exploring parameter space

Dear Ted, I solved it! :) just now obfunc newgraph() { localobj xtmp, ytmp, ztmp ytmp = $o1.c // make copies of the data to be plotted xtmp = $o2.c ztmp = $o3.c vsaved.append(ytmp) // save these copies tsaved.append(xtmp) psaved.append(ztmp) ztmp.plot(gb,xtmp) gb.exec_menu("View = plot") gb.label(0....
by menica
Tue May 24, 2016 10:22 am
Forum: Optimization
Topic: Exploring parameter space
Replies: 5
Views: 7527

Re: Exploring parameter space

Dear Ted, thanks, now the things are working well, but I still didn't solve the plotting problem. I substitute the newgraph() function which was creating a new graph at each run with a proc plotdata(). Now I can create 2 windows graph , each one for the quantity that I want to plot at every run on t...
by menica
Fri May 20, 2016 11:59 am
Forum: Optimization
Topic: Exploring parameter space
Replies: 5
Views: 7527

Exploring parameter space

I want to see what happens to the model changing each parameter, having the AP shape fixed. I don't understand what the sentence means. Changing a parameter will change the shape of the action potential. I want to change same parameters of the model to define their range values which does not affec...
by menica
Thu Apr 28, 2016 7:42 am
Forum: Optimization
Topic: MRF to explore parameter space
Replies: 3
Views: 14592

MRF to explore parameter space

Hi, I start using the Fitting tool of NEURON. I would like to explore the parameters space of my model, but I find out that this tool is more suitable for fitting the model outputs with experiments and then refine the model parameters. I am wondering if there is a way to use this tool to perform a s...
by menica
Wed Apr 13, 2016 1:42 pm
Forum: Adding new mechanisms and functions to NEURON
Topic: different mechanisms and temperature
Replies: 6
Views: 9062

Re: different mechanisms and temperature

Dear Ted, thanks, it is clear. Last question to see if I understood correctly. If I set the celsius=37, let's say, in the hoc code and all the mechanisms inserted in the model are intented to be used at exactly at that temperature as kv.mod, should be not necessary use the bias current? Otherwise, i...
by menica
Wed Apr 13, 2016 6:55 am
Forum: Adding new mechanisms and functions to NEURON
Topic: different mechanisms and temperature
Replies: 6
Views: 9062

Re: different mechanisms and temperature

Dear Ted, thanks for your answer. Looking at the code used in: Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 It is a model suitable for neocortical dendtrite. I was wandering if I could use these na.mod and kv.mod ins...