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Hi Ted, I am performing patch-clamp experiments and the estimate of tau comes from a depolarisation step. This is a standard protocol called seal test or sometimes membrane test. Thanks for raising a number of interesting points. I am trying to look into action potential backpropagation, hence I was...

Hi Ted, Thanks again for taking time to respond to my questions. The half width of a spike is only about 1 ms, much shorter than membrane time constant Actually, the time constants that I am seeing are on the same order as my AP half widths, around 1.5 ms (measured at the soma, granted). Where exact...

Hi Ted, Thanks very much for getting back to me and sorry for not clarifying enough. In myelinated or nonmyelinated axon? Prediction for nonmyelinated axon: Rm has no effect as long as membrane isn't grossly leaky. In nonmyelinated axons. Why do you say that it won't have any effect? Surely tau is g...

Hi all, I would like to see how conduction velocity changes in response to changes in membrane resistance. Not just theoretically though, but using experimentally determined values. From whole-cell voltage clamp experiments I have estimates of the conduction velocity, membrane resistance and membran...

Hi there, I am a complete newbie to NEURON and just want to replicate some data from a paper. So, I installed NEURON and downloaded the model they are using (Stuart and Spruston, 1998). Everything works fine so far. Now they talk about simulating an IPSP by a conductance change with reversal potenti...