Search found 7 matches

by Bonic
Wed Dec 05, 2018 6:07 am
Forum: General questions and discussions about computational neuroscience
Topic: membrane potential dependency from ion concentrations?
Replies: 9
Views: 1785

Re: membrane potential dependency from ion concentrations?

Is it too late to ask the instructors or institution for a tuition refund? In germany (where i study) students do not pay fees for public university education. As medical students, the physiology professors did not really expect us to understand the depth of electrophysiology (most medical students...
by Bonic
Sat Dec 01, 2018 10:02 am
Forum: General questions and discussions about computational neuroscience
Topic: membrane potential dependency from ion concentrations?
Replies: 9
Views: 1785

Re: membrane potential dependency from ion concentrations?

Hey Ted, Thanks again for your detailed response. This thread helped me to a great degree to develop a visual concept of what is happening in the cell so far. But you can't inject impermeant ions by themselves, either by bulk injection or simple diffusion, because they will be accompanied by counter...
by Bonic
Tue Nov 27, 2018 5:13 pm
Forum: General questions and discussions about computational neuroscience
Topic: membrane potential dependency from ion concentrations?
Replies: 9
Views: 1785

Re: membrane potential dependency from ion concentrations?

Again, thanks for your patience and help Ted. I really appreciate your inputs and you effort in order to help me. if i increase the internal potassium concentration (for example by current injection), the cell will hyperpolarize according to Goldman Equation (and the increased chemical gradient). My...
by Bonic
Mon Nov 26, 2018 7:23 pm
Forum: General questions and discussions about computational neuroscience
Topic: membrane potential dependency from ion concentrations?
Replies: 9
Views: 1785

Re: membrane potential dependency from ion concentrations?

i would assume the increased potassium concentration in the cell would have depolarized the cell in the first place . . . What If i would increase for example the outside calcium concentration (or the concentration of any other ion the cell has little/no permability for)? It would be very useful to...
by Bonic
Mon Nov 26, 2018 4:07 pm
Forum: General questions and discussions about computational neuroscience
Topic: membrane potential dependency from ion concentrations?
Replies: 9
Views: 1785

membrane potential dependency from ion concentrations?

Hello everybody, In my thesis i will work with NEURON. In order to understand the NEURON simulations better, i refresh my neurophysiology knownledge. Thereby, some questions came up, i stuck with. May you can help me. For example, if i increase the internal potassium concentration (for example by cu...
by Bonic
Mon Nov 26, 2018 12:16 pm
Forum: Getting started
Topic: Different questions regarding HOC- and NEURON
Replies: 3
Views: 1045

Re: Different questions regarding HOC- and NEURON

Hey Ted,

Thank you very much for you answer. By switching to the Python-Tutorial i will follow your advice and not burden myself with confusing HOC syntax anymore.
by Bonic
Thu Nov 22, 2018 5:34 am
Forum: Getting started
Topic: Different questions regarding HOC- and NEURON
Replies: 3
Views: 1045

Different questions regarding HOC- and NEURON

Hey, At the moment i try to learn HOC with a Tutorial provided by the MIT as i will need to make NEURON-Simulation in my thesis. Thereby some questions came up, you may can help me with: Firstly, it was striking that in HOC you always have to declare "objectvariables" with for example "objectvar sti...