www.neuron.yale.edu

Thanks, Ted!

In transcranial electric stimulation (TES) the applied E field amplitude at the level of the targeted cortex underneath the electrode is approximately 0.5V/m. Typically not more than 2mA of current is applied at the scalp electrodes to achieve such an E field amplitude. It’s not possible to go much ...

I have been using the impedance tool in neuron and would like to understand it’s origin in more depth than appears in the documentation. In particular I would like a better understanding of how the transfer impedance (as calculated by NEURON) follows from the active cable equation and under what ass...

Thanks Ted!

What about for pyramidal cells? Can my question be answered definitively for them?

Cheers!

Hi Ted I (a physicist) am a newbie to the detailed understanding of electrophysiology so I really appreciate your feedback! I guess this is what I am trying to get my head around: I am assuming that there presently exists a model for spontaneous oscillations in neurons (spontaneous in a manner simil...

Hi Ted

I am not sure that answers my question.

Hi Ted

By intrinsic subthreshold oscillations I mean spontaneous subthreshold oscillations. Presumably the model must account for spontaneous oscillations much differently than oscillations that are forced upon it by an extrinsic source.

At subthreshold levels of injected current I am guessing that the passive membrane conductance is much greater than the conductance of voltage-gated channels. Is this true? If so then at what transmembrane potential do the voltage-gated conductances start to dominate. Bit of a newbie question!

Some neurons display intrinsic spontaneous subthreshold oscillations. For subthreshold extrinsic (applied) electrical stimuli (current injection or magnetic induction) the HH equations can often be linearized and the solutions of these equations are good predictors in this subthreshold regime. My qu...

Thanks Ted

I will be taking a look very soon. This is great!

Yep, I figured you had spikes on your mind hence my gentle nudge back toward the subthreshold and linear systems.

Ted

Subthreshold systems are often described by linearized equations. At steady state they will oscillating at the driving frequency of the input current. No spikes are produced. The Fourier transform of the response is called the frequency response of the system.

Hi

I am new to NEURON. Does it have a means for calculating the frequency response function between input (injected curren) and output (membrane potential) sites for subthreshold stimuli using a linear model?

Thank you!