Simulation of large networks: technique and progress

TitleSimulation of large networks: technique and progress
Publication TypeJournal Article
Year of Publication2008
AuthorsLytton, William W., Stewart Mark, and Hines M. L.
JournalComputational neuroscience in epilepsy

Computer models of epilepsy and seizures require simulation of large networks 
in order to produce emergent phenomenology, but also require inclusion of details of 
cellular and synaptic physiology to retain connection with pharmacological effectors for 
therapeutic intervention. The former constraint suggests the use of simplifying approaches: 
integrate-and-fire models or meanfield approximations.

Full Text

Addresses issues involved in implementing and using computational models of large-scale networks, and how these issues are addressed in the context of the NEURON simulation environment.