Parameter | Description |
Ra | cytoplasmic resistivity |
cm | specific membrane capacitance |
g_pas | specific membrane conductance everywhere except apical dendrites |
A0 | minimum value of the sigmoidal function of distance that governs specific membrane conductance in the apical dendrites |
A | A + A0 is the maximum value of the sigmoidal function |
d | distance at which specific conductance in the apical dendrites is halfway between A0 and A + A0 |
But we're not going to have the MRF access these directly. Instead, we want to tell the MRF to control the surrogate variables Ra_, cm_, g_pas_, A0_, A_, and d_.
The surrogate variables will appear in the left panel of the MRF.
Save the MRF to a session file!
Viewing (and changing) parameter values
Click on the MRF's
Parameters / Parameter Panel
Change cm_ and see what happens. In the Parameter panel, increase cm_ to 2, then click on Error Value in the iclamp soma Generator. To restore cm_ back to its original value, click on the checkbox to the right of the cm_ button.
The checkboxes to the left of the parameter buttons specify which parameters the MRF is allowed to adjust. A check mark means the MRF can alter that parameter's value.
At this point we have set up the iclamp soma Generator, which emulates protocol 1, and told the MRF what parameters to optimize.
The next step is to try optimizing the model with this Generator.